A lignan with diverse biological activities; an AChE inhibitor (IC50 = 7.84 µM); scavenges ABTS and DPPH radicals (IC50s = 24.5 and 203 µM

Gomisin D – 10 mg

Brand:
Cayman
CAS:
60546-10-3
Storage:
-20
UN-No:
Non-Hazardous - /

Gomisin D is a lignan that has been found in S. chinensis and has diverse biological activities, including enzyme inhibitory and antioxidant properties.{52842,52843,47352} It inhibits acetylcholinesterase (AChE) with an IC50 value of 7.84 µM.{52842} Gomisin D scavenges ABTS (Item No. 27317) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50s = 24.5 and 203 µM, respectively).{47352} It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A3 by 89.9 and 83.1%, respectively, when used at a concentration of 100 µM.{52843} It is selective for UGT1A1 and UGT1A3 over other UGT isoforms at 100 µM.  

 

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SKU: 30697 - 10 mg Category:

Description

A lignan with diverse biological activities; an AChE inhibitor (IC50 = 7.84 µM); scavenges ABTS and DPPH radicals (IC50s = 24.5 and 203 µM, respectively); inhibits UGT1A1 and UGT1A3 by 89.9 and 83.1%, respectively, at 100 µM; selective for UGT1A1 and UGT1A3 over other UGT isoforms

Formal name: (5S,6S,7S,13aR,16R,17R)-5,6,7,8-tetrahydro-6,17-dihydroxy-1,2,3-trimethoxy-6,7,16,17-tetramethyl-5,13-(epoxybutanoxy)benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-18-one

Synonyms: 

Molecular weight: 530.6

CAS: 60546-10-3

Purity: ≥98%

Formulation: A crystalline solid

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