Scavenges oxygen radicals and reduces the production of ROS by inhibiting neutrophil activity; attenuates respiratory burst in rat peripheral neutrophils via suppression of NADPH oxidase (39% inhibition at 30 µg/ml) and inhibition of cytosolic calcium release from intracellular stores (36% inhibition at 50 µg/ml)

Gomisin C – 5 mg

Brand:
Cayman
CAS:
58546-56-8
Storage:
-20
UN-No:
Non-Hazardous - /

Gomisin C, a lignan first isolated from the fruits of S. chinensis, scavenges oxygen radicals and reduces the production of reactive oxygen species by inhibiting neutrophil activity.{30125} It has been shown to attenuate respiratory burst in rat peripheral neutrophils via suppression of NADPH oxidase (39% inhibition at 30 µg/ml) and inhibition of cytosolic calcium release from intracellular stores (36% inhibition at 50 µg/ml).{30126} Gomisin C can induce liver microsomal cytochrome P450, thus facilitating the clearance of xenobiotics and protecting against hepatotoxicity in rodent models of liver injury.{30124}  

 

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Description

Scavenges oxygen radicals and reduces the production of ROS by inhibiting neutrophil activity; attenuates respiratory burst in rat peripheral neutrophils via suppression of NADPH oxidase (39% inhibition at 30 µg/ml) and inhibition of cytosolic calcium release from intracellular stores (36% inhibition at 50 µg/ml)

Formal name: (5S,6S,7S,13aS)-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5,6-diol 5-benzoate

Synonyms:  Schisantherin A

Molecular weight: 536.6

CAS: 58546-56-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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