A potent Nampt inhibitor (IC50 = 5 nM); has antiproliferative activity in U251 glioblastoma

GNE-617 – 25 mg

Brand:
Cayman
CAS:
1362154-70-8
Storage:
-20
UN-No:
Non-Hazardous - /

GNE-617 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 5 nM).{38184} It has antiproliferative activity in U251 glioblastoma, HT-1080 fibrosarcoma, PC3 prostate, MiaPaCa2 pancreatic, and HCT116 colon cancer cell lines (IC50s = 1.8, 2.1, 2.7, 7.4, and 2.0 nM, respectively). In a U251 mouse xenograft model, GNE-617 (25 mg/kg once per day) led to rapid tumor regression.  

 

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Description

A potent Nampt inhibitor (IC50 = 5 nM); has antiproliferative activity in U251 glioblastoma, HT-1080 fibrosarcoma, PC3 prostate, MiaPaCa2 pancreatic, and HCT116 colon cancer cell lines (IC50s = 1.8, 2.1, 2.7, 7.4, and 2.0 nM, respectively); led to rapid tumor regression in a U251 mouse xenograft model at a dose of 25 mg/kg once per day,

Formal name: N-[[4-[(3,5-difluorophenyl)sulfonyl]phenyl]methyl]-imidazo[1,2-a]pyridine-6-carboxamide

Synonyms: 

Molecular weight: 427.4

CAS: 1362154-70-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins

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