A cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM); blocks glucagon-induced hepatic glycogenolysis in vivo

Glycogen Phosphorylase Inhibitor – 1 mg

Brand:
Cayman
CAS:
648926-15-2
Storage:
-20
UN-No:
Non-Hazardous - /

Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM).{28561} It blocks glucagon-induced hepatic glycogenolysis in vivo.{28561} Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.{28560,28558,28559}  

 

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Description

A cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM); blocks glucagon-induced hepatic glycogenolysis in vivo

Formal name: 2-chloro-4,5-difluoro-N-[[[2-methoxy-5-[[(methylamino)carbonyl]amino]phenyl]amino]carbonyl]-benzamide

Synonyms:  GPI

Molecular weight: 412.8

CAS: 648926-15-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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