A glycine-conjugated form of deoxycholic acid; induces a reversible

Glycodeoxycholic Acid (hydrate) – 250 mg

Brand:
Cayman
CAS:
1079043-81-4
Storage:
-20
UN-No:
Non-Hazardous - /

Glycodeoxycholic acid (GDCA) is a glycine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 18231 | 20756).{48223} It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits.{33912,33913} Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.{33914} GDCA levels are also increased in the plasma of patients with asthma.{33911}  

 

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Description

A glycine-conjugated form of deoxycholic acid; induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding CYP7A1 in rabbits; serum levels are elevated in non-surviving patients with AALF compared with survivors; plasma levels are increased in the plasma of patients with asthma

Formal name: N-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]-glycine, monohydrate

Synonyms:  GDCA

Molecular weight: 467.6

CAS: 1079043-81-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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