A glycine-conjugated form of cholic acid; has roles in the emulsification of fats; reduces expression of the gene encoding FXR and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells at 1.6 μmol/ml; increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells at 250 μM

Glycocholic Acid – 1 g

Brand:
Cayman
CAS:
475-31-0
Storage:
-20
UN-No:
Non-Hazardous - /

Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid (Item No. 20250) and has roles in the emulsification of fats.{48223,54310} It reduces expression of the gene encoding the farnesoid X receptor (FXR) and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells when used at a concentration of 1.6 μmol/ml.{54311} Glycocholic acid (250 μM) increases the intracellular accumulation and cytotoxicity of epirubicin (Item No. 12091) in Caco-2 cells, as well as decreases expression of the genes encoding multidrug resistance protein 1 (MDR1), MDR-associated protein 1 (MRP1), and MRP2 when used alone or in combination with epirubicin.{54312} It increases absorption of epirubicin into everted sacs of rat ileum and jejunum when used at a concentration of 250 μM. The bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases.{54311} Serum levels of glycocholic acid are elevated in patients with hepatocellular carcinoma compared with healthy individuals.{54310}  

 

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Description

A glycine-conjugated form of cholic acid; has roles in the emulsification of fats; reduces expression of the gene encoding FXR and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells at 1.6 μmol/ml; increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells at 250 μM, as well as decreases expression of the genes encoding MDR1, MRP1, and MRP2 when used alone or in combination with epirubicin; increases absorption of epirubicin into everted sacs of rat ileum and jejunum at 250 μM; bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases; serum levels are elevated in patients with hepatocellular carcinoma compared with healthy individuals,

Formal name: N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-glycine

Synonyms:  Cholylglycine|GCA

Molecular weight: 465.6

CAS: 475-31-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cancer|Cell Death||Research Area|Cancer|Multidrug Resistance||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome

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