An internal standard for the quantification of glycochenodeoxycholic acid by GC- or LC-MS

Glycochenodeoxycholic Acid-d4 – 1 mg

Brand:
Cayman
CAS:
1201918-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

An internal standard for the quantification of glycochenodeoxycholic acid (GCDCA; Item No. 16942) by GC- or LC-MS. GCDCA is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Item No. 10011286).{57144} It reduces formation of cholic acid (Item No. 20250) in primary human hepatocytes when used at a concentration of 100 µM.{57145} GCDCA (50, 75, and 100 µM) reduces the number LC3 puncta, a marker of autophagy, and is cytotoxic to L-02 hepatocytes.{57144} GCDCA (50 µM) induces apoptosis in isolated rat hepatocytes, an effect that can be blocked by the protein kinase C (PKC) inhibitor chelerythrine (Item No. 11314).{57146} Fecal levels of GCDCA are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}  

 

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Description

An internal standard for the quantification of glycochenodeoxycholic acid by GC- or LC-MS

Formal name: N-[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine

Synonyms:  GCDCA-d4

Molecular weight: 453.7

CAS: 1201918-16-2

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Lipid Biochemistry|Sterol Lipids

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