A cell-permeable

Glutaminase Inhibitor Compound 968 – 10 mg

Brand:
Cayman
CAS:
311795-38-7
Storage:
-20
UN-No:
Non-Hazardous - /

Glutaminase inhibitor compound 968 is a cell-permeable, reversible inhibitor of a mitochondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells.{31957,31958} Through this action, glutaminase inhibitor compound 968 blocks transformation induced by Rho GTPases and inhibits the proliferation of non-invasive epithelial (T-47D and MDA-MB-361) and invasive mesenchymal (MDA-MB-231 and Hs578T) cancer cells, without affecting normal cells.{31958,31955,31956} Glutaminase inhibitor compound 968 induces apoptosis and alters both histone methylation and gene expression in cancer cells.{31956}  

 

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Description

A cell-permeable, reversible inhibitor of a mitochondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells; blocks transformation induced by Rho GTPases and inhibits the proliferation of cancer cell lines without affecting normal cells

Formal name: 5-[3-bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethyl-benzo[a]phenanthridin-4(1H)-one

Synonyms: 

Molecular weight: 475.4

CAS: 311795-38-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|GTPases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|GTPases

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