An inhibitor of GLS1 (IC50 = 0.021 μM); inhibits the growth of NCI H1703 NSCLC cells in vitro (GI50 = 0.011 μM); reduces tumor growth

GLS1 Inhibitor – 5 mg

Brand:
Cayman
CAS:
1832646-52-2
Storage:
-20
UN-No:
Non-Hazardous - /

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM).{50176} It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.  

 

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SKU: 28581 - 5 mg Category:

Description

An inhibitor of GLS1 (IC50 = 0.021 μM); inhibits the growth of NCI H1703 NSCLC cells in vitro (GI50 = 0.011 μM); reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model at 100 mg/kg

Formal name: αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-benzeneacetamide

Synonyms: 

Molecular weight: 411.5

CAS: 1832646-52-2

Purity: ≥98%

Formulation: A crystalline solid

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