A mixture of globotetraosylceramides; the major glycolipids in human erythrocytes; act as receptors for the Shiga toxins Stx1

Globotetraosylceramides (porcine RBC) – 5 mg

Brand:
Cayman
CAS:
11034-93-8
Storage:
-20
UN-No:
Non-Hazardous - /

Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes.{43016} They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19.{43017,43018,43019} Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways.{43020} Levels of globotetraosylceramides are elevated in fibroblasts from patients with salt and pepper syndrome, a neurocutaneous condition characterized by intellectual disability and hyper- and hypo-pigmented skin.{43021} Globotetraosylceramides (porcine RBC) contains a mixture of globotetraosylceramides with variable fatty acyl chain lengths isolated from porcine red blood cells. [Matreya, LLC. Catalog No. 1068]  

 

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SKU: 24881 - 5 mg Category:

Description

A mixture of globotetraosylceramides; the major glycolipids in human erythrocytes; act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19; increase the expression of proteins responsible for enamel deposition in dental epithelial cells; levels of globotetraosylceramides are elevated in fibroblasts from patients with salt and pepper syndrome

Formal name: 1-O-[O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→3)-O-α-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide

Synonyms:  ,Globotetrahexosylceramides (porcine RBC),|Gb4Cers (porcine RBC)|Globosides (porcine RBC)

Molecular weight: 1,339.70

CAS: 11034-93-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Shigellosis||Research Area|Lipid Biochemistry|Sphingolipids

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