An inducer of stop codon read-through; restores the kinase activity of ATM in patient-derived A-T lymphoblastoid cell lines containing homozygous TAG

GJ-103 (sodium salt) – 10 mg

Brand:
Cayman
CAS:
1459687-96-7
Storage:
-20
UN-No:
Non-Hazardous - /

GJ-103 is an inducer of stop codon read-through.{46443} It restores the kinase activity of ataxia-telangiectasia mutated kinase (ATM) in patient-derived ataxia telangiectasia (A-T) lymphoblastoid cell lines containing homozygous TAG, TGA, or TAA nonsense mutations in ATM when used at concentrations of 10 and 30 μM.  

 

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Description

An inducer of stop codon read-through; restores the kinase activity of ATM in patient-derived A-T lymphoblastoid cell lines containing homozygous TAG, TGA, or TAA nonsense mutations in ATM at 10 and 30 μM

Formal name: 2-[[4-(3-methoxyphenyl)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid, monosodium salt

Synonyms: 

Molecular weight: 364.4

CAS: 1459687-96-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience|Neurodegenerative Disorders

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