A ginsenoside with diverse biological activities; enhances NK cytotoxicity against K562 cells in vitro at 10 µM and in vivo; reduces atherosclerotic lesion area

Ginsenoside F1 – 5 mg

Brand:
Cayman
CAS:
53963-43-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{59505,59506,59508,59507} It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo.{59505} GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice.{59506} It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).{59508} GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{59507}  

 

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Description

A ginsenoside with diverse biological activities; enhances NK cytotoxicity against K562 cells in vitro at 10 µM and in vivo; reduces atherosclerotic lesion area, whole body MPO levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice at 50 mg/kg; increases microvessel density and improves focal cerebral blood perfusion in a rat model of MCAO-induced ischemic stroke; restores spatial working memory in the APP/PS1 transgenic mouse model of Alzheimer’s disease

Formal name: (3β,6α,12β)-3,6,12-trihydroxydammar-24-en-20-yl β-D-glucopyranoside

Synonyms:  GF1|Panaxoside A Progenin

Molecular weight: 638.9

CAS: 53963-43-2

Purity: ≥98%

Formulation: A crystalline solid

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