A metabolite of ginsenoside Rb1; formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase; reduces protein levels of MMP-2 and pro-MMP-9

Ginsenoside CK – 25 mg

Brand:
Cayman
CAS:
39262-14-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ginsenoside CK is a metabolite of the saponin ginsenoside Rb1 (Item No. 15319) that has diverse biological activities.{52367,52368,52369,52370} Ginsenoside CK is formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase.{52367} It reduces protein levels of matrix metalloproteinase-2 (MMP-2) and pro-MMP-9 in, and inhibits growth, adhesion, and invasion of, MHCC97-H human hepatocellular carcinoma cells (HCCs) when used at concentrations of 50 and 75 µM.{52368} It inhibits metastasis in an MHCC97-H mouse xenograft model but does not reduce tumor growth. Ginsenoside CK reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis.{52369} It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42; Item No. 20574) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion.{52370} It also increases the percentage of time spent in the target quadrant of the Morris water maze when administered at doses of 100 and 200 mg/kg in the same model.  

 

Available on backorder

Add to quotes
SKU: 29926 - 25 mg Category:

Description

A metabolite of ginsenoside Rb1; formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase; reduces protein levels of MMP-2 and pro-MMP-9, and inhibits growth, adhesion, and invasion of, MHCC97-H HCCs at 50 and 75 µM; inhibits metastasis in an MHCC97-H mouse xenograft model; reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis; reduces the accumulation of Aβ42 in the rat hippocampal CA1 and CA3 regions in a rat model of vascular dementia; also increases the percentage of time spent in the target quadrant of the Morris water maze at 100 and 200 mg/kg in a rat model of vascular dementia

Formal name: (3β,12β)-3,12-dihydroxydammar-24-en-20-yl, β-D-glucopyranoside

Synonyms:  Ginsenoside Compound K|Ginsenoside IH901

Molecular weight: 622.9

CAS: 39262-14-1

Purity: ≥95%

Formulation: A crystalline solid

Related products

  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 25 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page