A terpene trilactone with diverse biological activities; inhibits PAF-induced platelet in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml

Ginkgolide J – 1 mg

Brand:
Cayman
CAS:
107438-79-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}  

 

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SKU: 29163 - 1 mg Category:

Description

A terpene trilactone with diverse biological activities; inhibits PAF-induced platelet in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively); inhibits Aβ42-induced cell death in primary rat hippocampal neurons and Aβ42-induced impairment of LTP in the mouse CA1 region at 1 μM

Formal name: (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-dimethylethyl)hexahydro-2,4,7b-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Synonyms:  BN 52024

Molecular weight: 424.4

CAS: 107438-79-9

Purity: ≥98%

Formulation: A solid

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