A potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM; demonstrates anticancer

Ginkgolide B – 50 mg

Brand:
Cayman
CAS:
15291-77-7
Storage:
-20
UN-No:
Non-Hazardous - /

Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}  

 

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Description

A potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM; demonstrates anticancer, anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects

Formal name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3’,2’:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Synonyms:  BN 52021|BN 52051

Molecular weight: 424.4

CAS: 15291-77-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Cycle||Research Area|Immunology & Inflammation|Allergy

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