Description
A terpenoid lactone with diverse biological activities; inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml); inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors (IC50 = 12 μM); reduces the proliferation rate of OVCA429 ovarian cancer cells by 40% at 100 μM; increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice at 1-2 mg/kg; reduces hexobarbital-induced sleeping time in mice by 44% at 10 mg/kg; increases CYP1A2 and CYP2E1 activity by 1.82- and 1.27-fold, respectively, in rats at 30 mg/kg per day
Formal name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Synonyms: BN-52020
Molecular weight: 408.4
CAS: 15291-75-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Lipids|Prenol Lipids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cancer||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety
