An antitumor antibiotic that inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein

Gilvocarcin V – 250 µg

Brand:
Cayman
CAS:
77879-90-4
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}  

 

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Description

An antitumor antibiotic that inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light

Formal name: 4-(6-deoxy-α-D-galactofuranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one

Synonyms:  Anandimycin A|Antibiotic 1072B|DC-38-V|NSC 338943|NSC 348115|Toromycin A

Molecular weight: 494.5

CAS: 77879-90-4

Purity: ≥98%

Formulation: A film

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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