A sesquiterpene with diverse biological activities; inhibits PRV replication in Vero cells from 10-150 µM; enhances doxorubicin-induced cytotoxicity and apoptosis in doxorubicin-resistant MCF-7/adr cells from 50-250 µM; reduces body weight gain

Germacrone – 5 mg

Brand:
Cayman
CAS:
6902-91-6
Storage:
-20
UN-No:
Non-Hazardous - /

Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.{48920,48921,48922,48923} It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.{48920} Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.{48921} In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.{48922} It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{48923}  

 

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SKU: 30111 - 5 mg Category:

Description

A sesquiterpene with diverse biological activities; inhibits PRV replication in Vero cells from 10-150 µM; enhances doxorubicin-induced cytotoxicity and apoptosis in doxorubicin-resistant MCF-7/adr cells from 50-250 µM; reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity at 5, 10, and 20 mg/kg; decreases brain MDA levels and activity of SOD and GPX, as well as reduces infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury

Formal name: (3E,7E)-3,7-dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one

Synonyms:  (E,E)-Germacrone

Molecular weight: 218.3

CAS: 6902-91-6

Purity: ≥98%

Formulation: A solid

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