Geraniol – 50 mg

Brand:
Cayman
CAS:
106-24-1
Storage:
-20
UN-No:
Non-Hazardous - /

Geraniol is a terpene alcohol found in a variety of plants, including Cannabis, that has diverse biological activities, including insecticide, antioxidant, anti-inflammatory, anticancer, and antimicrobial properties.{42303,39970} Geraniol is an insecticide that induces 100% mortality of C. maculatus, when used at a concentration of 16 µl in an alimentary substrate.{39971} It has an LD50 value of 0.714 µl in C. maculatus but does not produce adverse effects in rats when administered in the diet at 10,000 ppm for 16 weeks.{39971,39970} Topical administration of geraniol (250 µg) prevents lipid peroxidation, increases glutathione (GSH) levels, and increases the activity of antioxidant enzymes, including catalase, glutathione reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase in a mouse skin model of oxidative stress and inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{39972} It also decreases the levels of TNF-α, IL-6, and IL-1β in the same model. Geraniol (100 mg/kg) inhibits HMG-CoA reductase and reduces lipogenesis in hamsters fed an atherogenic diet as a model of hyperlipidemia when administered at a dose of 100 mg/kg.{39973} It also induces apoptosis in and decreases viability of COLO 205 cancer cells (IC50 = 20 µM).{42326} Formulations containing geraniol have been used as fragrance ingredients and as insecticides in agriculture.  

 

Available on backorder

SKU: 23166 - 50 mg Category:

Description

A terpene alcohol with diverse biological activities; an insecticide that induces 100% mortality of C. maculatus at 16 µl in an alimentary substrate (LD50 = 0.714 µl); no adverse effects in rats at 10,000 ppm in the diet for 16 weeks; prevents lipid peroxidation, increases the levels of GSH, the activity of various antioxidant enzymes, and the levels of cytokines in a mouse skin model of TPA-induced oxidative stress and inflammation at a topical dose of 250 µg; inhibits HMG-CoA reductase and reduces lipogenesis in a hamster model of hyperlipidemia induced by an atherogenic diet at 100 mg/kg; induces apoptosis in and decreases viability of COLO 205 cancer cells (IC50 = 20 µM)


Formal name: 3,7-dimethyl-2E,6-octadien-1-ol

Synonyms:  (E)-Geraniol|NSC 9279|β-Geraniol

Molecular weight: 154.3

CAS: 106-24-1

Purity: ≥98%

Formulation: A liquid


Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Toxicology|Environmental|Agriculture