A tannin with diverse biological activities; scavenges DPPH (IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9

Geraniin – 50 mg

Brand:
Cayman
CAS:
60976-49-0
Storage:
-20
UN-No:
Non-Hazardous - /

Geraniin is a tannin that has been found in P. urinaria and has diverse biological activities.{55054,48977,48978} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays.{55054} Geraniin inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively).{48977} It inhibits angiotensin-converting enzyme (ACE) in vitro (IC50 = 13.22 μM) and reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg.{55054} Geraniin (5, 10, and 20 μM) induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells.{48978} It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 10 and 20 mg/kg.  

 

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SKU: 29924 - 50 mg Category:

Description

A tannin with diverse biological activities; scavenges DPPH (IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays; inhibits HSV-1 and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively); inhibits ACE (IC50 = 13.22 μM); reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats at 5 mg/kg; induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells at 5, 10, and 20 μM; reduces tumor growth in an A549 mouse xenograft model at 10 and 20 mg/kg

Formal name: cyclic 2→7:4→5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-methano-2H-1-benzoxocin-5,7-dicarboxylate) cyclic 3,6-(4,4′,5,5′,6,6′-hexahydroxy[1,1′-biphenyl]-2,2′-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), β-D-glucopyranose, stereoisomer

Synonyms:  NSC 359346

Molecular weight: 952.6

CAS: 60976-49-0

Purity: ≥98%

Formulation: A crystalline solid

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