A benzoic acid with diverse biological activities; decreases radiation-induced production of TBARS

Gentisic Acid – 25 g

Brand:
Cayman
CAS:
490-79-9
Storage:
-20
UN-No:
Non-Hazardous - /

Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.{51131,51132,51133,51134,51135} It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.{51131} Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.{51132} It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).{51133} Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.{51134} It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.{51135}  

 

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SKU: 27615 - 25 g Category:

Description

A benzoic acid with diverse biological activities; decreases radiation-induced production of TBARS, hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes from 5-100 μM; inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma from 1-10 μM; induces relaxation of isolated guinea pig trachea (EC50 = 20 μM); reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy at 10 and 100 mg/kg; prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock

Formal name: 2,5-dihydroxy-benzoic acid

Synonyms:  5-Hydroxysalicylic Acid|Carboxyhydroquinone|NSC 27224|NSC 49098|NSC 78825

Molecular weight: 154.1

CAS: 490-79-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Cardiomyopathy||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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