An isoflavonoid phytoestrogen with kinase inhibitory

Genistein – 250 mg

Brand:
Cayman
CAS:
446-72-0
Storage:
-20
UN-No:
Non-Hazardous - /

Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}  

 

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SKU: 10005167 - 250 mg Category:

Description

An isoflavonoid phytoestrogen with kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties; inhibits EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively); reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model at 50 mg/kg per day; increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by DES at 50 mg/kg per day administered on postnatal days 1-5; reduces lipid accumulation and inflammation in the liver of OVX and non-OVX female rats in a model of high-fat high-fructose diet-induced model of NASH at 16 mg/kg per day; inhibits HIV-1 DNA synthesis in resting CD4+ T cells at 10 µM

Formal name: 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  CI-75610|NSC 36586

Molecular weight: 270.2

CAS: 446-72-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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