An iridoid glycoside with diverse biological activities; inhibits TPA-induced ear edema in mice by 91.01% when administered topically at 0.1 mg/ear; increases survival rate

Geniposidic Acid – 250 mg

Brand:
Cayman
CAS:
27741-01-1
Storage:
-20
UN-No:
Non-Hazardous - /

Geniposidic acid is an iridoid glycoside that has been found in G. jasminoides and has diverse biological activities.{46445,46444,46446} It inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice by 91.01% when administered topically at a dose of 0.1 mg/ear.{46445} Geniposidic acid (50 mg/kg) increases survival rate, attenuates increases in alanine aminotransferase (ALT) activity and TNF-α levels in serum, as well as hepatic levels of malondialdehyde (MDA), and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine (Item No. 22981) and LPS.{46444} It decreases systolic blood pressure and heart rate and increases plasma levels of atrial natriuretic peptide (ANP; Item Nos. 24276 | 24539) in spontaneously hypertensive rats when administered at a dose of 100 mg/kg.{46446}  

 

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Description

An iridoid glycoside with diverse biological activities; inhibits TPA-induced ear edema in mice by 91.01% when administered topically at 0.1 mg/ear; increases survival rate, attenuates increases in ALT activity and TNF-α levels in serum, as well as hepatic levels of MDA, and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine and LPS at 50 mg/kg; decreases systolic blood pressure and heart rate and increases plasma levels of ANP in spontaneously hypertensive rats at 100 mg/kg

Formal name: (1S,4aS,7aS)-1-(β-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid

Synonyms: 

Molecular weight: 374.3

CAS: 27741-01-1

Purity: ≥98%

Formulation: A crystalline solid

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