A fibrate that activates PPARα (EC50 = 193 μM) with 100% efficacy and PPARγ (EC50 = 148 μM) with 79% efficacy; lowers triglycerides and increases HDL cholesterol levels; strongly binds liver fatty acid-binding protein (Ki = 1.8 μM)

Gemfibrozil – 5 g

Brand:
Cayman
CAS:
25812-30-0
Storage:
-20
UN-No:
Non-Hazardous - /

Gemfibrozil is a fibrate that activates peroxisome proliferator-activator α (PPARα, EC50 = 193 μM) with 100% efficacy.{23621} It also activates PPARγ (EC50 = 148 μM), but with only 79% efficacy.{23621} Presumably through its effects on PPARα, gemfibrozil lowers triglycerides and increases high density lipoprotein cholesterol levels and is used in the context of atherogenic dyslipidemia.{23620} Gemfibrozil strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).{23622} Phase II metabolites of gemfibrozil inhibit certain cytochrome P450 isoforms, increasing drug-drug interaction risks.{23619}  

 

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Description

A fibrate that activates PPARα (EC50 = 193 μM) with 100% efficacy and PPARγ (EC50 = 148 μM) with 79% efficacy; lowers triglycerides and increases HDL cholesterol levels; strongly binds liver fatty acid-binding protein (Ki = 1.8 μM)

Formal name: 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid

Synonyms:  CI-719|Lopid

Molecular weight: 250.3

CAS: 25812-30-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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