A major metabolite of gemfibrozil; formed when gemfibrozil undergoes glucuronidation by UDP2B7; a CYP2C8 inhibitor (IC50 = 4.1 µM); taken up by OATP1B1 in SCHHs; inhibits cellular uptake of valsartan in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM)

Gemfibrozil 1-O-β-Glucuronide – 1 mg

Brand:
Cayman
CAS:
91683-38-4
Storage:
-20
UN-No:
Non-Hazardous - /

Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil (Item No. 14835) that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7.{37643} Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan (Item No. 14178) in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).{37644,37645}  

 

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Description

A major metabolite of gemfibrozil; formed when gemfibrozil undergoes glucuronidation by UDP2B7; a CYP2C8 inhibitor (IC50 = 4.1 µM); taken up by OATP1B1 in SCHHs; inhibits cellular uptake of valsartan in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM)

Formal name: 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate], β-D-glucopyranuronic acid

Synonyms: 

Molecular weight: 426.5

CAS: 91683-38-4

Purity: ≥85%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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