An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary

Gemcitabine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
122111-03-9
Storage:
-20
UN-No:
Non-Hazardous - /

Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}  

 

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SKU: 9003096 - 100 mg Category:

Description

An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition); inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay; decreases MuLV cell infectivity (EC50 = ~1.5 nM); inhibits the progression of murine AIDS in vivo

Formal name: 2′-deoxy-2′,2′-difluoro-cytidine, monohydrochloride

Synonyms: 

Molecular weight: 299.7

CAS: 122111-03-9

Purity: ≥98%

Formulation: A crystalline solid

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