A prodrug form of gemcitabine; inhibits growth of gemcitabine-sensitive L1210/L5

Gemcitabine Elaidate – 5 mg

Brand:
Cayman
CAS:
210829-30-4
Storage:
-20
UN-No:
Non-Hazardous - /

Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Item Nos. 11690 | 9003096) that contains an elaidic acid (Item No. 90250) moiety.{47590} Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 µM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 µM). It inhibits growth of THX, LOX, MOLT-4, and MOLT-4/C8 cells in a manner independent of nucleoside transport. Gemcitabine elaidate reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models but not in an H-146 small cell lung cancer mouse xenograft model when administered at a dose of 40 mg/kg every three days.  

 

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SKU: 28303 - 5 mg Category:

Description

A prodrug form of gemcitabine; inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells or gemcitabine-resistant AG6000 cells; reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models at 40 mg/kg every three days

Formal name: 2′-deoxy-2′,2′-difluoro-cytidine, 5′-(9E)-9-octadecenoate

Synonyms:  CP 4126

Molecular weight: 527.6

CAS: 210829-30-4

Purity: ≥98%

Formulation: A crystalline solid

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