A potent and selective ERK1/2 inhibitor (IC50s = 6.1 and 4.1 nM

GDC-0994 – 500 µg

Brand:
Cayman
CAS:
1453848-26-4
Storage:
-20
UN-No:
Non-Hazardous - /

GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively.{33248} It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.{33248}  

 

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Description

A potent and selective ERK1/2 inhibitor (IC50s = 6.1 and 4.1 nM, respectively); cell-permeable and orally bioavailable

Formal name: 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone

Synonyms:  RG-7842

Molecular weight: 440.9

CAS: 1453848-26-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling

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