A modulator of sickle hemoglobin; increases HbS affinity for oxygen (EC50s = 8.2 and 415 μM for purified HbS and whole blood from sickle cell anemia patients

GBT-440 – 1 mg

Brand:
Cayman
CAS:
1446321-46-5
Storage:
-20
UN-No:
Non-Hazardous - /

GBT-440 is a modulator of sickle hemoglobin (HbS) that binds covalently to the N-terminal valine of the α chain of HbS.{41378} In vitro, GBT-440 increases HbS affinity for oxygen (EC50s = 8.2 and 415 μM for purified HbS and whole blood from sickle cell anemia patients, respectively) and delays oxygen release from and polymerization of HbS in a concentration-dependent manner. GBT-440 (100-150 mg/kg) increases red blood cell half-life and reduces sickling ex vivo in whole blood isolated from a murine model of sickle cell anemia. It also reduces ex vivo sickling of sickle cell trait red blood cells under conditions of hypoxia, acidosis, and dehydration.{41379}  

 

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SKU: 23933 - 1 mg Category:

Description

A modulator of sickle hemoglobin; increases HbS affinity for oxygen (EC50s = 8.2 and 415 μM for purified HbS and whole blood from sickle cell anemia patients, respectively); delays oxygen release from and polymerization of HbS in a concentration-dependent manner; increases red blood cell half-life and reduces sickling ex vivo in whole blood isolated from a murine model of sickle cell anemia

Formal name: 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde

Synonyms:  Voxelotor

Molecular weight: 337.4

CAS: 1446321-46-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin

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