An inhibitor of dopamine uptake; binds to the dopamine transporter (Kd = 27.2 nM); selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM

GBR 12935 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
67469-81-2
Storage:
-20
UN-No:
Non-Hazardous - /

GBR 12935 is an inhibitor of dopamine uptake that binds to the dopamine transporter (Kd = 27.2 nM).{22877,36625} It is selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively).{22877} In mice, it increases locomotor activity, but not stereotypic behavior, when administered at a dose of 10 mg/kg but induces gnawing at levels similar to other indirect dopamine agonists with an ED50 value of 17.1 mg/kg.{36625,36626}  

 

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Description

An inhibitor of dopamine uptake; binds to the dopamine transporter (Kd = 27.2 nM); selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively); it increases locomotor activity in mice at 10 mg/kg; induces gnawing in mice (ED50 = 17.1 mg/kg),

Formal name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride

Synonyms: 

Molecular weight: 487.5

CAS: 67469-81-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience

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