An inhibitor of oxidative phosphorylation in cancer cells; increases the mitochondrial membrane potential and inhibits the oxygen consumption rate

Gboxin – 5 mg

Brand:
Cayman
CAS:
2101315-36-8
Storage:
-20
UN-No:
Non-Hazardous - /

Gboxin is an inhibitor of oxidative phosphorylation in cancer cells, which have a higher mitochondrial proton gradient and pH compared with non-cancerous cells.{35805} It increases the mitochondrial membrane potential and reduces the oxygen consumption rate, which can be bypassed by the proton ionophore FCCP (Item No. 15218), indicating that it inhibits F0F1 ATP synthase/complex V. Gboxin decreases viability of three primary mouse glioblastoma cell lines (IC50s = ~150 nM) and three patient-derived glioblastoma cultures (IC50s = ~1 µM) but does not affect the viability of primary mouse embryonic fibroblasts or astrocytes. It halts the cell cycle in the G1/G0 phase and induces apoptosis of primary low-passage glioblastoma cells pooled from multiple tumors.  

 

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SKU: 27861 - 5 mg Category:

Description

An inhibitor of oxidative phosphorylation in cancer cells; increases the mitochondrial membrane potential and inhibits the oxygen consumption rate, indicating F0F1 ATP synthase/complex V inhibition; decreases viability of three primary mouse glioblastoma cell lines (IC50s = ~150 nM) and three patient-derived glioblastoma cultures (IC50s = ~1 µM) but does not affect the viability of primary mouse embryonic fibroblasts or astrocytes; halts the cell cycle and induces apoptosis

Formal name: 2-ethyl-1-methyl-3-[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-1H-benzimidazolium, monochloride

Synonyms: 

Molecular weight: 393

CAS: 2101315-36-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis

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