A phenolic glycoside with diverse biological activities; reduces Aβ42-induced cell death of rat hippocampal neurons and BV-2 mouse microglia; improves learning and memory in various transgenic mouse models of Alzheimer's disease; reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease; reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures from 50-200 mg/kg; increases social interaction and decreases marble burying and grooming behaviors

Gastrodin – 250 mg

Brand:
Cayman
CAS:
62499-27-8
Storage:
-20
UN-No:
- /

Gastrodin is a phenolic glycoside that has been found in Gastrodia and has diverse biological activities.{46514,46515,46516,46517} It reduces cell death of rat hippocampal neurons and BV-2 mouse microglia induced by amyloid-β (1-42) (Aβ42; Item No. 20574) and improves learning and memory in various transgenic mouse models of Alzheimer’s disease.{46514} It reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330). Gastrodin (50-200 mg/kg) reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures. In a mouse model of valproic acid-induced autistic-like phenotypes, gastrodin (100 mg/kg) increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala.{46515} Gastrodin increases ultimate breaking force and bone stiffness, measures of biomechanical strength, in a rat model of osteoporosis induced by dexamethasone (Item No. 11015).{46516} It also inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease.{46517}  

 

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Description

A phenolic glycoside with diverse biological activities; reduces Aβ42-induced cell death of rat hippocampal neurons and BV-2 mouse microglia; improves learning and memory in various transgenic mouse models of Alzheimer’s disease; reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson’s disease; reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures from 50-200 mg/kg; increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala in a mouse model of valproic acid-induced autistic-like phenotypes at 100 mg/kg; increases biomechanical bone strength in a rat model of dexamethasone-induced osteoporosis; inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease

Formal name: 4-(hydroxymethyl)phenyl β-D-glucopyranoside

Synonyms: 

Molecular weight: 286.3

CAS: 62499-27-8

Purity: ≥98%

Formulation: A crystalline solid

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