Description
A peptide hormone; binds to CCK receptors on human gastric leiomyosarcoma cells (IC50 = 0.9 nM) and in guinea pig gallbladder and pancreatic tissue (IC50s = 1.7 and 2.5 μM, respectively); increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM) and stimulates pepsinogen secretion by isolated human peptic cells (ED50 = 30 nM); increases gastric acid secretion in vivo in rats (1 nmol/kg/h)
Formal name: 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
Synonyms: Gastrin Heptadecapeptide I (human)|Gastrin I (1-17) (human)
Molecular weight: 2,098.20
CAS: 10047-33-3
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization
