An inhibitor of the HATs p300 and pCAF (IC50 = 7 and 5 μM

Garcinol – 5 mg

Brand:
Cayman
CAS:
78824-30-3
Storage:
-20
UN-No:
Non-Hazardous - /

Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).{14406} It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.{20146} A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.{20148,20145} Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.{20147,20144}  

 

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SKU: 10566 - 5 mg Category:

Description

An inhibitor of the HATs p300 and pCAF (IC50 = 7 and 5 μM, respectively) that also inhibits the HAT Gcn5; promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells; induces apoptosis in several types of cancer cells and has anti-inflammatory actions

Formal name: 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione

Synonyms:  Camboginol

Molecular weight: 602.8

CAS: 78824-30-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Stem Cell Research|Proliferation||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Fungal Diseases||Research Area|Neuroscience

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