An oxygenated triterpenoid; inhibits glucose uptake and lactate production at 50-200 µM and decreases pyruvate and acetyl-coenzyme A production at 100 and 200 µM in HT-29 and SW620 colon cancer cells; increases protein levels of SIRT3 in HT-29 and SW620 cells; cytotoxic to HepG2

Ganoderic Acid D – 10 mg

Brand:
Cayman
CAS:
108340-60-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ganoderic acid D is an oxygenated triterpenoid that has been found in G. lucidum.{46301} It inhibits glucose uptake and lactate production when used at concentrations ranging from 50 to 200 µM and decreases pyruvate and acetyl-coenzyme A production at concentrations of 100 and 200 µM in HT-29 and SW620 colon cancer cells. Ganoderic acid D increases protein levels of sirtuin 3 (SIRT3) in HT-29 and SW620 cells. It is cytotoxic to HepG2, HeLa, and Caco-2 cells with IC50 values of 0.14, 0.18, and 0.02 µg/ml, respectively.{46302}  

 

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SKU: 26765 - 10 mg Category:

Description

An oxygenated triterpenoid; inhibits glucose uptake and lactate production at 50-200 µM and decreases pyruvate and acetyl-coenzyme A production at 100 and 200 µM in HT-29 and SW620 colon cancer cells; increases protein levels of SIRT3 in HT-29 and SW620 cells; cytotoxic to HepG2, HeLa, and Caco-2 cells (IC50s = 0.14, 0.18, and 0.02 µg/ml, respectively)

Formal name: 7β-hydroxy-3,11,15,23-tetraoxo-lanost-8-en-26-oic acid

Synonyms: 

Molecular weight: 514.7

CAS: 108340-60-9

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death||Research Area|Cancer|Metabolism

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