Description
A triterpene with diverse biological activities; reduces cell viability, expression SOD1, SOD2, and SOD3, and production of ROS in PC3 prostate cancer cells; reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes from 2-100 μg/ml; inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia; reduces lung MPO activity, neutrophil infiltration, and NF-κB signaling, as well as BALF levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury at 20 and 40 mg/kg; reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity
Formal name: (25R)-7β,15α-dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid
Synonyms:
Molecular weight: 516.7
CAS: 81907-62-2
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Tumor Microenvironment||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
