Description
A GNRHR antagonist (IC50 = 3.6 nM; pA2 = 9.3); induces a concentration-dependent increase in histamine release from rat peritoneal mast cells in vitro (EC50 = 11 μg/ml); decreases plasma testosterone in intact male rats for the first 7 days post-administration (2 mg/kg, s.c.); decreases the surface area of endometriotic lesions and serum progesterone levels in female baboons (125 μg per day for 30 days)
Formal name: N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[(ethylamino)(ethylimino)methyl]-D-lysyl-L-leucyl-N6-[(ethylamino)(ethylimino)methyl]-L-lysyl-L-prolyl-D-alaninamide, diacetate
Synonyms:
Molecular weight: 1,690.40
CAS: 129311-55-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity
