A mixture of bovine ganglioside GT1b with variable fatty acyl chain lengths; characterized by having two sialic residues linked to the inner galactose unit; binds to the neurotoxins BTxA

Ganglioside GT1b Mixture (bovine) (ammonium salt) – 5 mg

Brand:
Cayman
CAS:
59247-13-1
Storage:
-20
UN-No:
- /

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.{37775} Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor.{25480} Ganglioside GT1b decreases spontaneous production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM.{25482} Ganglioside GT1b Mixture contains bovine ganglioside GT1b molecular species with variable fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1063]  

 

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SKU: 31712 - 5 mg Category:

Description

A mixture of bovine ganglioside GT1b with variable fatty acyl chain lengths; characterized by having two sialic residues linked to the inner galactose unit; binds to the neurotoxins BTxA, BTxA heavy chain, and tetanus toxin (IC50s = 11, 0.74, and 7.2 μM, respectively); ganglioside GT1b-containing liposomes can bind to the major coat protein VP1 from MCPyV, a putative MCPyV receptor; decreases spontaneous production of IL-6, IL-10, IgG, IgM, and IgA in human PBMCs by 31.4, 30.5, 60, 59.5, and 58%, respectively, at 10 μM

Formal name:

Synonyms:  Ganglioside G1

Molecular weight: 2,180.50

CAS: 59247-13-1

Purity: ≥98%

Formulation: A solid

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