A mixture of ganglioside GQ1b with C18:1 and C20:1 sphingoid backbones; stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells at 5 nM; promotes differentiation of mESCs to neuronal precursor and glial cells via activation of the ERK1/2 pathway; induces differentiation of murine keratinocytes through phophoinositide turnover

Ganglioside GQ1b Mixture (sodium salt) – 500 µg

Brand:
Cayman
CAS:
68652-37-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. It stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells when used at a concentration of 5 nM.{25486} Ganglioside GQ1b promotes differentiation of murine embryonic stem cells (mESCs) to neuronal precursor and glial cells via activation of the ERK1/2 pathway.{25483} It also induces differentiation of murine keratinocytes through phosphoinositide turnover.{25487} Ganglioside GQ1b mixture contains ganglioside GQ1b molecular species with C18:1 and C20:1 sphingoid backbones.  

 

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Description

A mixture of ganglioside GQ1b with C18:1 and C20:1 sphingoid backbones; stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells at 5 nM; promotes differentiation of mESCs to neuronal precursor and glial cells via activation of the ERK1/2 pathway; induces differentiation of murine keratinocytes through phophoinositide turnover

Formal name:

Synonyms: 

Molecular weight: 2,508.50

CAS: 68652-37-9

Purity: ≥98%

Formulation: A lyophilized solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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