A mixture of ganglioside GM2 asialo with variable fatty acyl chain lengths; a ganglioside lacking the sialic acid residue; levels are low-to-undetectable in normal human brain

Ganglioside GM2 Asialo Mixture – 100 µg

Brand:
Cayman
CAS:
35960-33-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.{40891} It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients.{40892} Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable lengths. [Matreya, LLC. Catalog No. 1512]  

 

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SKU: 24629 - 100 µg Category:

Description

A mixture of ganglioside GM2 asialo with variable fatty acyl chain lengths; a ganglioside lacking the sialic acid residue; levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease; binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients

Formal name: 1-O-[O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide

Synonyms:  Asialo-GM2|Asialoganglioside GM2|Gangliotriaosylceramide

Molecular weight: 1,093.40

CAS: 35960-33-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders

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