A mixture of ganglioside GD3 with C18:1 and C20:1 sphingoid backbones; induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential at 200 μM; expression in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro; ganglioside GD3-deficient adult mice exhibit progressive loss of the NSC pool and impaired neurogenesis

Ganglioside GD3 Mixture (sodium salt) – 1 mg

Brand:
Cayman
CAS:
62010-37-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases.{31218} It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM.{5033} Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro.{28470} Ganglioside GD3-deficient adult mice exhibit progressive loss of the neural stem cell (NSC) pool and impaired neurogenesis.{37782} Ganglioside GD3 mixture contains ganglioside GD3 molecular species with C18:1 and C20:1 sphingoid backbones.  

 

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Description

A mixture of ganglioside GD3 with C18:1 and C20:1 sphingoid backbones; induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential at 200 μM; expression in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro; ganglioside GD3-deficient adult mice exhibit progressive loss of the NSC pool and impaired neurogenesis

Formal name:

Synonyms:  Disialosyllactosylceramide Mixture

Molecular weight: 1,516.70

CAS: 62010-37-1

Purity: ≥98%

Formulation: A lyophilized powder

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Cell Biology|Stem Cell Research||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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