A positive modulator of GABAA receptor complexes containing α1

Ganaxolone – 10 mg

Brand:
Cayman
CAS:
38398-32-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current.{32575,28852} At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes.{32575,28852} Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.{30563,27521,29670}  

 

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Description

A positive modulator of GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits; has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials

Formal name: (3α,5α)-3-hydroxy-3-methyl-pregnan-20-one

Synonyms:  CCD 1042

Molecular weight: 332.5

CAS: 38398-32-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Seizure Disorders

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