A galanin receptor agonist (KD = 2.9 µM in Bowes cells expressing GAL1 receptors); inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 µM); reduces the maximal seizure score and increases the latency to first seizure in a mouse model of PTZ-induced seizures at 2 mg/kg; reduces cocaine-induced motor activity and frontal cortex

Galnon (trifluoroacetate salt) – 5 mg

Brand:
Cayman
CAS:
1217448-19-5
Storage:
-20
UN-No:
Non-Hazardous - /

Galnon is a galanin (GAL) receptor agonist (KD = 2.9 µM in Bowes cells expressing GAL1 receptors).{53507} It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole (PTZ; Item No. 18682). It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.{53508} Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.{53509}  

 

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SKU: 29925 - 5 mg Category:

Description

A galanin receptor agonist (KD = 2.9 µM in Bowes cells expressing GAL1 receptors); inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 µM); reduces the maximal seizure score and increases the latency to first seizure in a mouse model of PTZ-induced seizures at 2 mg/kg; reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats; reduces food intake in rats and mice from 1.5-5 mg/kg

Formal name: 3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide, trifluoroacetate salt

Synonyms:  Fmoc-β-Cha-Lys-AMC

Molecular weight: 792.9

CAS: 1217448-19-5

Purity: ≥98%

Formulation: A crystalline solid

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