A polyphenol with diverse biological activities; inhibits TPA-induced intracellular ROS production and DNA damage in human PMNs at 1 μM; decreases TPA-induced nitric oxide release by 90% from primary rat hepatocytes at 0.5 mM; inhibits HCV entry into Huh7.5 human hepatoma cells (IC50 = 5.8 μM); inhibits the proliferation of MDA-MB-231 and MCF-7 human breast cancer cells (IC50s = 2.5 and 4 μM

Gallotannin – 5 g

Brand:
Cayman
CAS:
5424-20-4
Storage:
-20
UN-No:
Non-Hazardous - /

Gallotannin is a polyphenol of gallic acid (Item No. 11846) that has been found in various plants and has antioxidant, anti-inflammatory, antiviral, and antiproliferative biological activities.{43122,43123,43124,43125} Gallotannin (1 μM) inhibits the intracellular production of reactive oxygen species (ROS) and DNA damage induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in human polymorphonuclear neutrophils (PMNs).{43122} It also decreases TPA-induced nitric oxide release by 90% from primary rat hepatocytes when used at a concentration of 0.5 mM.{43123} Gallotannin inhibits hepatitis C virus (HCV) entry into Huh7.5 human hepatoma cells (IC50 = 5.8 μM) and inhibits the proliferation of MDA-MB-231 and MCF-7 human breast cancer cells (IC50s = 2.5 and 4 μM, respectively).{43124,43125} In a rat model of middle cerebral artery occlusion (MCAO), it increases superoxide dismutase (SOD1) protein levels and decreases the amount of proteins modified by malondialdehyde (MDA) in ischemic brain tissue when administered at a dose of 10 mg/kg.{43126}  

 

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Description

A polyphenol with diverse biological activities; inhibits TPA-induced intracellular ROS production and DNA damage in human PMNs at 1 μM; decreases TPA-induced nitric oxide release by 90% from primary rat hepatocytes at 0.5 mM; inhibits HCV entry into Huh7.5 human hepatoma cells (IC50 = 5.8 μM); inhibits the proliferation of MDA-MB-231 and MCF-7 human breast cancer cells (IC50s = 2.5 and 4 μM, respectively); increases SOD1 protein levels and decreases the amount of MDA-modified proteins in a rat model of MCAO at 10 mg/kg

Formal name: 1,2,3,4,6-pentakis[3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoate]β-D-glucopyranose

Synonyms:  Tannic Acid

Molecular weight: 1,701.20

CAS: 5424-20-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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