A blue dye used to stain nuclei that is known to inhibit Dkk1-LRP5/6 interactions (IC50 = 3 µM)

Gallocyanine – 10 g

Brand:
Cayman
CAS:
1562-85-2
Storage:
-20
UN-No:
Non-Hazardous - /

Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 µM), thereby activating Wnt/β-catenin signaling.{32876} Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.{32876}  

 

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Description

A blue dye used to stain nuclei that is known to inhibit Dkk1-LRP5/6 interactions (IC50 = 3 µM), thereby activating Wnt/β-catenin signaling; inhibits PGJ2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro

Formal name: 1-carboxy-7-(dimethylamino)-3,4-dihydroxy-phenoxazin-5-ium, monochloride

Synonyms:  Alizarine Navy Blue|Anthracene Blue SWGG|Brilliant Chrome Blue P|C.I. 51030|Fast Violet|IIIC3|Mordant Blue 10

Molecular weight: 336.7

CAS: 1562-85-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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