A fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC50 = 0.25-0.5 μM) by blocking the binding of activated STAT3 dimers to DNA; 10-50 μM exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3

Galiellalactone – 500 µg

Brand:
Cayman
CAS:
133613-71-5
Storage:
-20
UN-No:
Non-Hazardous - /

Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM.{24943} The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor.{24943} At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.{24944}  

 

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Description

A fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC50 = 0.25-0.5 μM) by blocking the binding of activated STAT3 dimers to DNA; 10-50 μM exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3

Formal name: (7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one

Synonyms: 

Molecular weight: 194.2

CAS: 133613-71-5

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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