An internal standard for the quantification of galantamine by GC- or LC-MS

Galantamine-d3 (hydrobromide) – 500 µg

Brand:
Cayman
CAS:
2140262-53-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Galantamine-d3 is intended for use as an internal standard for the quantification of galantamine by GC- or LC-MS. Galantamine is an alkaloid originally isolated from the bulbs and flowers of Galanthus that inhibits acetylcholinesterase (AChE; IC50 = 636 nM).{25283} It reverses growth inhibition and inhibits apoptosis, autophagic flux, and production of reactive oxygen species (ROS) induced by amyloid-β (Aβ) in neuronally differentiated PC12 cells.{48082} Galantamine prevents soman toxicity and inhibits acetylcholinesterase in cynomolgus macaques (ED50s = 590 and 362 μg/kg, respectively).{48083} It also decreases escape latency in the Morris water maze and the total hippocampal area of Aβ plaques in an APP/PS1 transgenic mouse model of Alzheimer’s disease.{48084}  

 

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SKU: 26103 - 500 µg Category:

Description

An internal standard for the quantification of galantamine by GC- or LC-MS

Formal name: (4aS,6R,8aS)-3-(methoxy-d3)-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol, monohydrobromide

Synonyms: 

Molecular weight: 371.3

CAS: 2140262-53-7

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Toxicology

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