A bioactive sphingolipid; potentiates LPS-induced production of inflammatory cytokines

Galactosylsphingosine (d18:1) – 1 mg

Brand:
Cayman
CAS:
2238-90-6
Storage:
-20
UN-No:
Non-Hazardous - /

Galactosylsphingosine is a bioactive sphingolipid.{32334,32333,15202} It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate (Item No. 10008639).{32334} Galactosylsphingosine (0.1 and 1 µM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes.{32033} Galactosylsphingosine (10 and 15 µM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells.{54403} Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.{32334,32333,15202,54403}[Matreya, LLC. Catalog No. 1305]  

 

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Description

A bioactive sphingolipid; potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes; induces demyelination of mouse cerebellar slices at 0.1 and 1 µM; inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes; inhibits PPARα-mediated gene transcription in C6 glial cells at 10 and 15 µM; levels are increased in postmortem brain from patients with Krabbe disease

Formal name: 2S-amino-3R-hydroxy-4E-octadecen-1-yl-β-D-galactopyranoside

Synonyms:  Galactosylsphingosine|Psychosine

Molecular weight: 461.6

CAS: 2238-90-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders

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