A potent inhibitor of human SGLT2 that is 1

galacto-Dapagliflozin – 1 mg

Brand:
Cayman
CAS:
1408245-02-2
Storage:
-20
UN-No:
Non-Hazardous - /

Renal glucose transport is mediated by sodium-glucose cotransporters (SGLT) 1 and 2.{20894} In humans, SGLT2 is responsible for the majority of glucose reabsorption in the kidney.{20894} galacto-Dapagliflozin is a potent inhibitor of human SGLT2 that is 1,000-fold less potent at human SGLT1 (Ki values are 2 and 25,000 nM, respectively).{20895} It also dissociates from hSGLT2 more slowly than from hSGLT1 (half-time off rates are 19 and 0.9 seconds, respectively).{20895}  

 

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Description

A potent inhibitor of human SGLT2 that is 1,000-fold less potent at human SGLT1 (Ki values are 2 and 25,000 nM, respectively); dissociates from hSGLT2 more slowly than from hSGLT1 (half-time off rates are 19 and 0.9 seconds, respectively)

Formal name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-galactitol

Synonyms: 

Molecular weight: 408.9

CAS: 1408245-02-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area

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