Immunogen: Synthetic peptide from the N-terminal region of the α3 subunit of the rat GABAA receptor • Host: Rabbit • Species Reactivity: (+) Mouse

GABAA Receptor α3 Subunit (N-Term) Polyclonal Antibody – 100 µl

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Cayman
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GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The α subunit of GABAA receptors interfaces with a β subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. GABAA α3 subunit expression is decreased in neocortical tissue samples surgically isolated from patients with medically refractory temporal lobe epilepsy.{55213} Knockdown of Gabra3, which encodes the α3 subunit isoform, prevents stress-induced colonic inflammation in mice.{55216} Cayman’s GABAA Receptor α3 Subunit (N-Term) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor α3 subunit at approximately 51 kDa from mouse and rat samples.  

 

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SKU: 29269 - 100 µl Category:

Description

Immunogen: Synthetic peptide from the N-terminal region of the α3 subunit of the rat GABAA receptor • Host: Rabbit • Species Reactivity: (+) Mouse, Rat • Applications: IHC, WB • MW = ~51 kDa

Synonyms: GABAA Receptor Subunit α3|GABRA3|γ-Aminobutyric Acid Receptor Subunit α3

Immunogen: Synthetic peptide from the N-terminal region of the α3 subunit of the rat GABAA receptor

Formulation: 100 µl of affinity-purified polyclonal antibody

Isotype:

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Seizure Disorders

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